He was born on July 18, 1972 in Heraklion Crete. He studied Surveying Engineering at the University of Applied Sciences (TEI) of Athens and he was trained in Environmental Management and Technology. He holds a Master's Degree in International Political Economy and International Relations acquired at University of Peloponnese.
He worked as a bank executive at Pancreta Bank. He has founded the company "Business (LP)" - Business and Technical Research Consultants», based in Heraklion. In 2007 he published his first book, under the title "Political Issues" (published by Ellinika Grammata), while in 2010 he published an e-book entitled "Public Administration: Time Zero. Even God feared the Greek State." He is an elected Member of the Greek Parliament (Heraklion constituency) with the Nea Demokratia (N.D.) party since 2007.
He served as the Head of Infrastructure, Transport and Networks Sector of the N.D. party. By decision of the President of N.D., Mr. Kyriakos Mitsotakis, on January 13, 2016, Lefteris Avgenakis was appointed as Deputy Secretary of the Political Committee of N. D. party. He was elected Secretary of the Political Committee of N.D. in April 2016 for the first time and he was re-elected in January 2019.
In July 2019 he was appointed Deputy Minister of Culture and Sports, with responsibilities for sports. He is married to educator Lena Bania and he has a son, named Konstantinos.